Monday, January 13, 2025

See Why (MAIA) is Topping Our Pre-Market Watchlist Right Now

*Sponsored


After Friday’s Biotech Moved Approximately 81% Ahead of the Bell, We’re Announcing Our Next Potential Breakout Idea For Today…


MAIA Biotechnology (NYSE: MAIA) is At The Top Of Our Radar Right Now!


MAIA Biotechnology (NYSE: MAIA) Comes Backed By Several Potential Catalysts That We Look For, Such As:


Late Friday night (MAIA) triggered 14 Bullish Signals on TradingView, including the Momentum Indicator, underscoring strong

near-term potential.


(MAIA) is Targeting Several High Value Markets Worth $34B, 

$20B, $3B, and $2B.


Recent Analyst Coverage Shows a Noble Capital Analyst Tagging (MAIA) with $14.00 which target suggests 573% upside potential. 


Keep reading to see why (MAIA) is On Our Radar In Today’s Pre-Market…









January 13, 2025



Dear Reader,



Are you awake yet?



The early bird doesn’t just get the worm—it gets the edge. 


Case in point: Friday’s biotech spotlight moved approximately 81% before the opening bell, getting early readers a reason to get excited.


This morning, our attention shifts to another standout that’s impossible to ignore: MAIA Biotechnology (NYSE: MAIA)—is topping our watchlist this morning.


If you’re serious about uncovering the next potential breakout, you should consider starting your research on (MAIA) while it’s still early.



You see, starting today, Dr. Vlad Vitoc, CEO of MAIA Biotechnology (NYSE: MAIA), is taking the stage at Biotech Showcase™ 2025, one of the industry’s most anticipated events. He’ll be unveiling pivotal updates on the THIO-101 Phase 2 trial expansion, focusing on advanced non-small cell lung cancer (NSCLC) patients receiving third-line (3L) therapy.

Plus, he’s expected to outline plans for future trials targeting multiple high-value cancer indications.


Let’s not forget the numbers. 


Just a few days ago, Noble Capital Markets’ Robert LeBoyer set a $14.00 target on MAIA—an eye-catching 573% upside from Friday’s $2.08 open. And Diamond Equity Research is equally bullish, with an $11.25 target pointing to 440% upside potential.


MAIA Biotechnology (NYSE: MAIA) is making headlines, and this morning’s spotlight is well-deserved. Don’t let this one slip by.


If you’re serious about spotting the next potential breakout, MAIA Biotechnology (NYSE: MAIA) needs to be on your radar today.


A few days ago, on January 8th, Noble Capital Markets’ Robert LeBoyer slapped a $14.00 target on (MAIA)—which suggests a potential 573% upside from Friday’s $2.08 open. But even before that, Diamond Equity Research set their target at $11.25, pointing to 440% upside potential.

And here’s the clincher: (MAIA) wasn’t just sitting idle on Friday night. Around 7:48 PM EST, it fired off 14 Bullish Signals on TradingView, including the coveted Momentum Indicator on the 5-minute chart.


If you haven’t heard of (MAIA) yet, consider this your wake-up call. 


A Game-Changer in Cancer Treatment


MAIA Biotechnology (NYSE: MAIA) lead asset, THIO (6-thio-dG), is the first and only telomere-targeting agent in clinical development. 


THIO operates with a dual mechanism of action (MoA): directly targeting telomeres to disrupt cancer cell replication while simultaneously activating an immune response to destroy the cancer cells.


The Phase 2 THIO-101 trial focuses on non-small cell lung cancer (NSCLC), a market worth a staggering $34B annually. 


Results?


Nothing short of groundbreaking. 


THIO followed by immune checkpoint inhibitors (ICIs) like Regeneron’s Libtayo® has demonstrated 60% complete response rates in preclinical models. 


Patients achieved sustained remission after just two cycles of therapy, with no cancer recurrence—even after rechallenge with 5x the initial cancer cell load. 

This isn’t just a treatment—it’s a potential revolution.


Market Potential: Unmet Needs, Unrivaled Potential

Cancer treatments are a high-stakes game, and (MAIA) is targeting the jackpot. 


NSCLC is the largest cancer market globally, and THIO is positioned to address patients who have become resistant to current checkpoint inhibitors—an enormous unmet need. 


The U.S. FDA has already recognized THIO’s promise, granting Orphan Designations for small cell lung cancer (SCLC), hepatocellular carcinoma (HCC), and glioblastoma (brain cancer).


Let’s talk numbers:


  • NSCLC: $34B annual sales.
  • Checkpoint Inhibitors: $46B global market in 2023, with Keytruda alone generating $9B in NSCLC sales.
  • HCC and SCLC: Combined annual sales of $5B with massive growth potential.


MAIA Biotechnology (NYSE: MAIA) owns worldwide rights to THIO, securing the company’s stake in every dollar these markets generate.


THIO-101: A Masterclass in Efficacy


The THIO-101 trial has set a new standard for cancer therapies. Patients treated with THIO + Libtayo® showed a disease control rate (DCR) of 85%, far surpassing the 25–35% DCR achieved by traditional chemotherapy. 


Even in third-line (3L) settings—where options are typically grim—THIO delivered unprecedented outcomes:


  • Median progression-free survival (PFS): 2.5 months (compared to 1.5 months with chemotherapy).
  • Median overall survival (OS): 5.8 months (nearly double the historical benchmark).
  • Objective response rate (ORR): 38%, a dramatic leap from the 6–10% seen with chemotherapy.


These results underscore one thing: THIO is not just effective; it’s transformative.


Building the Pipeline: (MAIA)’s Vision for the Future


(MAIA) isn’t stopping at NSCLC. With a robust pipeline of trials planned for colorectal cancer (CRC), SCLC, HCC, and other solid tumors, the company is poised to address multiple high-value cancer indications. 


Interestingly, preclinical models in CRC demonstrated a 100% complete response rate with long-term immune memory formation.


The strategy? 


Expand THIO’s applications while leveraging collaborations with big pharma players like Regeneron. 


MAIA Biotechnology (NYSE: MAIA) Expands Collaboration with Regeneron, a +$76B Industry Leader

Less than six weeks ago, on December 3, 2024, MAIA Biotechnology (NYSE: MAIA) announced the expansion of its clinical supply agreement with Regeneron, a +$76B industry leader, for the ongoing Phase 2 THIO-101 trial. 


This partnership focuses on evaluating MAIA's lead asset, THIO, in combination with Regeneron’s Libtayo® (cemiplimab), an immune checkpoint inhibitor. 


The trial targets advanced non-small cell lung cancer (NSCLC) patients resistant to prior checkpoint inhibitor therapies and chemotherapy.


Initially signed in 2021, the agreement was designed to supply Libtayo® during the dose selection and safety evaluation stages. 


The expanded agreement now supports a broader patient population to assess THIO’s efficacy at the optimal dose. Regeneron provides Libtayo® for all trial patients, while MAIA sponsors the study and retains exclusive global rights to develop and commercialize THIO.


This collaboration highlights Regeneron's confidence in THIO’s potential to enhance checkpoint inhibitor outcomes. 


With THIO demonstrating promising disease control, progression-free survival, and overall response rates, MAIA Biotechnology (NYSE: MAIA) is advancing its regulatory pathway and exploring the potential for accelerated U.S. approval based on trial results. 


Beyond the expansion of THIO-101, the company is systematically building a robust pipeline of Phase 2/3 trials, including THIO-102 (targeting CRC, HCC, and SCLC) and THIO-103 (first-line NSCLC). 


Together, these initiatives position MAIA as a biotech powerhouse with a portfolio designed for long-term growth.


Intellectual Property: Locking in the Advantage


(MAIA)’s intellectual property portfolio is as robust as its science. The company holds five issued patents and 29 pending applications covering telomere-targeting compounds and THIO’s immunogenic treatment strategy. 


With exclusivity agreements extending to 2041, MAIA is ensuring its technology remains unrivaled for decades.


Leadership: Experience That Delivers


MAIA Biotechnology (NYSE: MAIA)’s team brings over 70 years of combined experience in oncology and biotech. 


CEO Dr. Vlad Vitoc has led the launch of 12 oncology compounds across 20 tumor types, while CSO Dr. Sergei Gryaznov—the co-inventor of THIO—is a global authority on telomeres and cancer. This isn’t their first rodeo, and it shows.


The Bottom Line


MAIA Biotechnology (NYSE: MAIA) is not just another biotech company. It’s a disruptor, a trailblazer, and quite possibly the future of cancer treatment. 


With a pipeline brimming with potential, collaborations with leading industry players, and a market valued in the high ranges, (MAIA) stands out as a company to keep on your radar.


In the fight against cancer, (MAIA) is bringing the big guns. 


And if their data is anything to go by, this is one company to keep an eye on.


5 Reasons MAIA Biotechnology (NYSE: MAIA) Is Topping Our

Watchlist This Morning…


1. Building Momentum: MAIA has triggered 14 Bullish Signals on TradingView, and all eyes are on CEO Dr. Vlad Vitoc at Biotech Showcase™ 2025, where he’s unveiling critical updates on THIO-101 and outlining ambitious plans for the future.


2. Analyst Targets: With Noble Capital Markets setting a $14.00 target (573% upside potential) and Diamond Equity Research estimating $11.25 (440% upside potential), (MAIA) is grabbing attention from analysts.


3. Tapping Into Large Markets: Targeting key oncology markets, including non-small cell lung cancer ($34B), colorectal cancer ($20B), liver cancer ($3B), and small cell lung cancer ($2B), (MAIA) is addressing areas of significant unmet need.


4. Revolutionary Science: THIO, the first telomere-targeting therapy in development, is achieving unprecedented outcomes—an 85% disease control rate and a 38% objective response rate that leave traditional therapies in the dust.


5. Competitive Edge in Innovation: (MAIA)’s five issued patents and 29 pending applications secure exclusivity through 2041, positioning the company as a leader in the emerging field of telomere-targeting cancer treatments.


Keeping An Eye On MAIA Biotechnology (NYSE: MAIA) This Week…


MAIA Biotechnology (NYSE: MAIA) is proving itself to be more than just another biotech—it’s a trailblazer in the fight against cancer. With 14 Bullish Signals recently triggered on TradingView and CEO Dr. Vlad Vitoc captivating audiences at Biotech Showcase™ 2025, the momentum is undeniable.


Analysts are taking notice, with targets from Noble Capital Markets and Diamond Equity Research pointing to an upside potential of 573% and 440%, respectively.


 And it’s not just projections driving excitement; (MAIA) is tackling some of oncology’s biggest markets, including non-small cell lung cancer ($34B) and colorectal cancer ($20B).


At the heart of this is THIO, a groundbreaking therapy delivering results that outshine traditional treatments with an 85% disease control rate and a 38% objective response rate. 


Combined with an ironclad intellectual property portfolio securing exclusivity through 2041, (MAIA) is not just leading—it’s redefining the telomere-targeting space.


If the data is any indication, MAIA Biotechnology (NYSE: MAIA) isn’t just making progress—it’s making history.


(MAIA) is at the top of our screens right now.


Consider pulling up (MAIA) and taking a look before the opening bell rings.


We have less than 45 minutes to go.


Watch for my next update.


Sincerely,


Jeff Ackerman

Managing Editor

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